Natural killer cell-mimicking nanomaterial for overcoming the multidrug resistance of tumor via cascade catalysis

Despite the availability and prosperity of chemotherapeutic agents, multidrug resistance (MDR) remains paramount obstacle in antitumor chemotherapy. Here, a natural killer (NK) cell-biomimetic nanoparticle (DMLN) is developed to overcome MDR by promoting entry doxorubicin (DOX) into tumor cells via cascade catalysis. DMLN synthesized compounding NK cell membrane with hollow MnO2 nanoparticles loaded DOX lactate oxidase (LOX). When it reaches microenvironment, can be degraded release Mn2+. A Fenton-like reaction subsequently occurs generates large amount •OH around membrane. will increase permeability plasma for diffusion cells. The high concentration intracellular MDR. Owing coating, maintain excellent blood circulation accumulation abilities. In vitro vivo experiments have verified remarkable effect against tumors. This cell-mimicking strategy provides promising modality treatment.